A Proven Method of Radiation Therapy

Clinical Resources

Many publications support the efficacy and safety of Breast Microseed Treatment®, a form of PBSI (permanent breast seed implantation). Peer-reviewed publications show that outcomes compare favorability to other forms of breast cancer radiation therapy, including:

  • Low chance of breast cancer recurrence
  • Side effects are less frequent and less severe
  • Reduced risk of infection
  • Reduced radiation damage to healthy tissue
  • Patients are extremely satisfied
  • Patient's breast cosmesis (breast appearance) is excellent

Disclosure: Concure Oncology does not own the rights to these journal articles and does not earn revenue from them. We provide links to relevant publications to facilitate physician’s research of Breast Microseed Treatment.

Clinical Study Publications

Report on the clinical outcomes of permanent breast seed implant for early-stage breast cancers.

Pignol JP et al. Int J Radiat Oncol Biol Phys, 93:3, 614-621, 2015.

  • The 5-year data suggest that permanent breast seed implantation is a safe accelerated partial breast irradiation option after lumpectomy for early-stage breast cancer with a tolerance profile similar to that of whole breast irradiation.

Tolerance and acceptance results of a palladium-103 permanent breast seed implant phase I/II study.

Pignol JP et al. Int J Radiat Oncol Biol Phys, 73:5, 1482-1488, 2009.

  • The feasibility, safety, and tolerability of PBSI compares favorably with that of external beam and other partial breast irradiation techniques.

First report of a Permanent Breast Seed Implant (PBSI) as adjuvant radiation for early stage breast cancer.

Pignol JP et al. Int J Radiat Oncol Biol Phys, 64:1, 176-181, 2006.

  • Permanent breast seed implantation seems feasible and well tolerated on these preliminary clinical data and represents an ultimate step in the reduction of treatment fraction for partial breast irradiation.

Peer-Reviewed Publications

Seed Placement in Permanent Breast Seed Implant Brachytherapy: Are Concerns Over Accuracy Valid? 

Morton D et al. Int J Radiat Oncol Biol Phys, 95:3, 1050-1057, 2016.

  • No significant trends or systematic errors were observed in the placement of seeds in PBSI, including seeds implanted directly into the seroma. Recorded seed displacements may be related to intrapatient setup adjustments. Despite observed seed displacements, acceptable postimplant dosimetry was achieved.

Skin dose in breast brachytherapy: Defining a robust metric. 

Hilts M et al. Brachytherapy, 14:6, 970-978, 2015.

  • Doses to small volumes are robust measures of breast skin dose and given skin's strong area effect, D0.2cc for a 2 mm thick skin layer, a simple surrogate of D1cm(2), is recommended for recording skin dose in any breast brachytherapy. Dmax is not robust and should be avoided.

Deformable image registration for defining the postimplant seroma in permanent breast seed implant brachytherapy. 

Hilts M et al. Brachytherapy, 14:3, 409-418, 2015.

  • Deformable image registration can be used to adapt the preimplant seroma to post implant PBSI images and is recommended for implant quality assurance in PBSI. Using deformable registration avoids uncertainties associated with poor seroma visualization and interobserver variability when rigid registration is performed. The accurate deformation of implanted surgical clips demonstrates the reliability of deformable image registration for PBSI.

Permanent Breast Seed Implant Dosimetry Quality Assurance. 

Keller B et al. Int J Radiat Oncol Biol Phys, 83:1, 84-92, 2012. 

  • Preplanning dosimetry should aim for a V(90) of approximately 100%, a V(100) between 95% and 100%, and a V(200) between 20% and 30%, as these numbers are associated with no local recurrences to date and good patient tolerance. In general, the target volume coverage improved over the duration of the seed therapy. The maximum skin dose, defined as the average dose over the hottest 1 × 1-cm(2) surface area, should be limited to 90% of the prescription dose to minimize delayed skin toxicity 

Doses to internal organs for various breast radiation techniques--implications on the risk of secondary cancers and cardiomyopathy.

Pignol JP et al. Radiat Oncol, 6:5, 2011.

  • The present data support the use of breast IMRT or virtual wedge technique instead of physical wedges for whole breast radiotherapy. Regarding partial breast irradiation techniques, low energy source brachytherapy and external beam 3D-CRT appear safer than 192Ir HDR techniques.

A radiation badge survey for family members living with patients treated with a 103Pd Permanent Breast Seed Implant. 

Keller B et al. Int J Radiat Oncol Biol Phys, 70:1, 267–271, 2008.

  • Based on measured and calculated spousal doses, a permanent breast seed implant using (103)Pd is safe for the public. However, it is recommended that extra precautions in the way of a breast patch be used when patients with an implant will be in the vicinity of toddlers or pregnant women.

Concure Oncology®

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Mike Ribaudo
Chief Medical Officer

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